Rodent Implant Model


Our new paper entitled “Preclinical In-Vivo Evaluation and Screening of Zinc Based Degradable Metals for Endovascular Stents” has been published in the JOM journal. Roger Guillory, PhD candidate, and Prof. Jeremy Goldman from Biomedical Engineering led this project, in which a metal wire implantation model in rats that our collaborative team introduced in 2012, is refined and described in details. This is a cost effective and realistic model for the biocompatibility evaluation of degradable materials in the vascular environment. In this new publication, metrics routinely used for evaluating stents to quantitatively characterize the long-term progression of the neointima that forms around zinc based wire implants were adapted. Histological cross-sections were used to measure the length of neointimal protrusion from the wire into the lumen (denoted wire to lumen thickness), the base neointimal length (describing the breadth of neointimal activation), and the neointimal area. These metrics were used to provide in depth characterization details for neointimal responses to Zn-Mg and Zn-Li alloys and may be used to compare different materials

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